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Interaction of multiple entities and receptors, or multivalency is widely applied to achieve high affinity ligands for diagnostic and therapeutic purposes. However, lack of knowledge on receptor distribution in living subjects remains a challenge for rational structure design. Herein, we develop a force measurement platform to probe the distribution and separation of the cell surface vascular endothelial...
Ein optimierter Ligand mit picomolarer Affinität wurde auf Basis der Geometrie geeigneter Linker für spezifische multivalente Bindungsmodi entworfen. Z. Li, S. Jiang et al. bestimmen in ihrer Zuschrift auf S. 5326 die Verteilung und Aufteilung von VEGF‐Rezeptoren auf lebenden Zellen mithilfe von Einzelmolekül‐Rasterkraftmessungen. Die Rezeptorverteilung wurde anschließend beim rationalen Design eines...
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