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Unipolar brush cells (UBCs), a class of interneurons in the vestibulocerebellum, play roles in amplifying excitatory inputs from vestibulocerebellar mossy fibers. This study aimed to clarify whether corticotropin-releasing factor (CRF)-positive mossy fiber innervation of calretinin (CR)-positive UBCs was altered in rolling mouse Nagoya (RMN). The distribution and the number of CR-positive UBCs in...
Rolling mouse Nagoya (RMN) is an ataxic mutant and carries a mutation in the gene coding for the α 1A subunit of the P/Q-type Ca 2+ channel. We examined the immunohistochemical expression of the α 1A subunit in deep cerebellar nuclei of RMN. The antibody used recognized residues 865–883 of the mouse α 1A subunit not overlapping the altered sequences in RMN. In RMN,...
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