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Bone morphogenetic protein 2 (BMP-2) is used clinically to stimulate bone formation and accelerate fracture repair. Adding prostaglandin (PG) E 2 or PGE 2 receptor agonists to BMP-2 has been proposed to improve BMP-2 efficacy. However, this may enhance bone resorption, since PGE 2 can increase receptor activator of NF-κB ligand (RANKL) expression and decrease osteoprotegerin...
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