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The effects of a sialic acid derivative, Neu5Acβ-PA, on the blood circulation and tissue distribution of liposomes composed of dipalmitoylphosphatidylcholine (DPPC), cholesterol (Chol) and Neu5Acβ-PA were investigated compared with liposomes composed of DPPC, Chol and monosialoganglioside GM 1 in mice and rats. When liposomes containing Neu5Acβ-PA were intravenously administered into mice,...
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