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The endothelin receptor subtypes involved in the vasoconstriction, capsular smooth muscle contraction, prostaglandin E 2 and prostacyclin release induced by endothelin-1 have been investigated in the canine isolated perfused spleen using both the endothelin ET A receptor antagonist FR 139317 and the endothelin ET B receptor agonist IRL 1620. The isolated canine spleen was...
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