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The uncertainty in crystallization kinetics is of major concern in manufacturing processes, which can result in deterioration of most model‐based control strategies. In this study, uncertainties in crystallization kinetic parameters were characterized by Bayesian probability distributions. An integrated B2B‐NMPC control strategy was proposed to first update the kinetic parameters from batch to batch...
Polymorphism is a phenomenon that a substance can have more than one crystal form, each with distinct characteristics. Consequently, controlling polymorphism in drug manufacturing industries are crucial in order to ensure consistent production of the desired polymorph. In this paper, a run-to-run concentration control (C-control) based on iterative learning control is developed. As a case study, a...
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