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Crizotinib, a drug for anaplastic lymphoma kinase (ALK) positive and c‐ros oncogene 1 receptor tyrosine kinase (ROS1) positive non‐small cell lung cancer (NSCLC), was structurally optimized via a strategy of structure‐based fragment replacing. Computational study showed it was beneficial for interaction of crizotinib and ALK to increase the distance between pyridyl ring and phenyl ring in crizotinib,...
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