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Inorganic arsenic (iAs) at high doses is a known human carcinogen, inducing tumors of the skin, urinary bladder, and lung. It is also associated with non-cancer toxicities. An understanding of the mode of action (MOA) for arsenic-induced effects is needed to develop a scientifically-based risk assessment. To determine an MOA for iAs induced toxicities, it is necessary to understand the metabolism,...
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