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Background
The clinical phenotype of patients with monogenic obesity due to mutations in the leptin receptor (LEPR) or melanocortin 4 receptor (MC4R) gene is characterized by impaired satiety and hyperphagia, leading to extreme, sometimes life‐threatening weight gain.
Subjects/methods
In a case series, we analysed the effect of an off‐label methylphenidate (MPH) use for 1 year as an individual...
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