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The goal of this work was to design a sandwich assay with electrochemical transduction for the detection of a tumor marker, human epidermal growth factor receptor 2 (HER2), using a simple target capturing step by antibody-functionalised magnetic beads. The HER2 proto-oncogene is amplified and/or overexpressed in approximately 20–25% of invasive breast cancers. The assay is based on a sandwich format...
The detection of DNA hybridization is of significant scientific and technological importance as testified by the growing interest in chip-based characterization of gene expression patterns and detection of pathogens. Recently, there has been an increasing interest for DNA sensors based on the SAMs (Self Assembled Monolayers) of Peptide Nucleic Acid (PNA) modified electrodes. PNA is a DNA mimic that...
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