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We report on the peak capacity that can be produced by operating a state-of-the-art core–shell particle type (d p =2.6μm) at its kinetic optimum at ultra-high pressures of 600 and 1200bar. The column-length optimization needed to arrive at this kinetic optimum was realized using column coupling. Whereas the traditional operating mode (using a single 15cm column operated at its optimum flow...
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