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In this issue, Li and Wedlich-Soldner [1] offer an alternative interpretation of the previously reported synthetic lethality of the bem1Δ rsr1Δ double mutant and suggest an alternative conclusion from our recent experiments involving rescue of that lethality, published in Current Biology [2]. However, findings presented in our recent paper [2] as well as in our earlier work [3] argue against their...
In 1952, Alan Turing suggested that spatial patterns could arise from homogeneous starting conditions by feedback amplification of stochastic fluctuations. One example of such self-organization, called symmetry breaking, involves spontaneous cell polarization in the absence of spatial cues. The conserved GTPase Cdc42p is essential for both guided and spontaneous polarization, and in budding yeast...
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