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Twenty novel 1,2,3‐triazole benzenesulfonamides featuring nitrile 8a–g, carbothioamide 9a–f, and N′‐hydroxycarboximidamide 10a–g functionalities were designed and synthesized to improve potency and selectivity as carbonic anhydrase inhibitors (CAIs). The synthesized 1,2,3‐triazole compounds were tested in vitro as CAIs against four physiologically and pharmacologically relevant isoforms of human carbonic...
Two series comprising 20 novel benzenesulfonamides bearing thioureido‐linked pyrazole 8 and amino‐1,2,4‐thiadiazole 10 were synthesized and assayed as human carbonic anhydrase (hCA) inhibitors against isoforms I and II as well as the tumor‐associated isoforms IX and XII. Molecular modeling studies of some potent derivatives (8a, 8c, 10a, and 10c) were also performed against isoforms hCA I, II, and...
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