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Prior studies from our laboratory have shown that ongoing myocyte death through apoptosis occurs in hibernating myocardium (HM). This study was designed to assess whether reperfusion after 7 days of severe coronary stenosis affects apoptosis in HM.Methods: Three groups of pigs were studied. In group 1 (n = 6) a fixed LAD stenosis was created, reducing LAD flow from 0.94 +/- 0.11 to 0.56 +/- 0.11...
We have previously shown that LV remodeling occurs in hibernating myocardium (HM), with wall thinning related to slippage of myocyte bundles and myocyte hypertrophy. To study whether reperfusion reverses these cellular changes, we created a LAD stenosis to reduce flow by 40% 5 pigs, producing severe regional LV dysfunction. At 7 days LV biopsies were taken from the hibernating and normal regions;...
Myocardial contrast perfusion echocardiography (MCE) has been used to assess myocardial viability in patients with ischemic LV dysfunction. To evaluate its ability to assess myocardial blood flow (MBF) in hibernating myocardium (HM), MCE was performed at 13 levels of reduced MBF in 6 pigs with HM (1 to 4 wks).Methods: The model of HM was created with a left anterior descending coronary stenosis to...
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