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The sequencing of the human genome was a major step in understanding the ways in which we are wired. Although an important milestone, this genetic blueprint provides only a ``parts list"; it does not offer any information about how the human organism is actually working, and it gives little insight into the function or interactions among the approximately thirty thousand constitutive parts that...
Determining the three-dimensional structure of a protein is an important step in understanding biological function. Despite advances in experimental methods (crystallography and NMR) and protein structure prediction techniques, the gap between the number of known protein sequences and determined structures continues to grow. Approaches to protein structure prediction vary from those that apply physical...
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