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How SIV progenitors evolved into deadly HIV‐1 and HIV‐2 following initial cross‐species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV‐2. Increased viral virulence to human CD4+ T cells and adaptive genetic changes were observed during serial passages.
HIV-2 is thought to have originated from an SIV progenitor native to sooty mangabeys. To model the initial human transmission and understand the sequential viral evolution, humanized mice were infected with SIVsm and serially passaged for five generations. Productive infection was seen by week 3 during the initial challenge followed by chronic viremia and gradual CD4+ T cell decline. Viral loads increased...
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