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Felty's syndrome (FS) is a rare association of rheumatoid arthritis (RA), neutropenia and splenomegaly. Mechanisms of neutropenia in FS are unclear but involve both innate and humoral immunity, impaired granulopoiesis and decreased granulocyte half-life. Several treatments have been used without clear efficiency. We report a patient with FS efficiently treated with rituximab (RTX), the monoclonal...
Le syndrome de Felty (SF) se caractérise par l’association rare d’une polyarthrite rhumatoïde (PR) avec une neutropénie et une splénomégalie. Les mécanismes de la neutropénie dans le SF ne sont pas clairs, mais impliquent à la fois l’immunité innée et humorale, une perturbation de la granulopoïèse et une diminution de la demi-vie des granulocytes. Plusieurs traitements ont été utilisés avec une efficacité...
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