Search results for: Ja-June Jang

Items from 1 to 20 out of 71 results

article

Assessment of acute, 14-day, and 13-week repeated oral dose toxicity of Tiglium seed extract in rats

Jun-Won Yun, Euna Kwon, Yun-Soon Kim, Seung-Hyun Kim, more

BMC Complementary and Alternative Medicine > 2018 > 18 > 1 > 1-12

Background Seed of mature Croton tiglium Linne, also known as Tiglium seed (TS), has been widely used as a natural product due to its several health beneficial properties including anti-tumor and antifungal activities. Despite its ethnomedicinal beneficial properties, toxicological information regarding TS extract, especially its long-term toxicity, is currently limited. Therefore, the objective of...

article

Nicotinamide suppresses cell growth by G1-phase arrest and induces apoptosis in intrahepatic cholangiocarcinoma

Yue Wang, Han Suk Ryu, Ja June Jang

Molecular & Cellular Toxicology > 2018 > 14 > 1 > 43-51

Intrahepatic cholangiocarcinoma (iCCA) is a devastating malignancy with no effective treatment. Nicotinamide (NA, the amide form of vitamin B3) has been shown to be effective in the treatment of various diseases. However, the effects of NA in iCCA have not been studied. In this study, four human iCCA cell lines (HuCCT1, JCK, OZ and Cho-CK) were used. We found that NA significantly inhibited cell viability...

article

Absence of subchronic oral toxicity and genotoxicity of rice koji with Aspergillus terreus

Jun-Won Yun, Seung-Hyun Kim, Yun-Soon Kim, Ji-Ran You, more

Regulatory Toxicology and Pharmacology > 2017 > 89 > C > 244-252

Koji products have been considered as an effective fermented food consumed in East Asia with many health benefits. Particularly, rice koji with Aspergillus terreus (RAT) has been reported to be able to prevent hyperlipidemia and hepatic steatosis through regulating cholesterol synthesis. Despite its biological activities, there is a lack of comprehensive information to give an assurance of its safety...

article

Tumoral LINE-1 hypomethylation is associated with poor survival of patients with intrahepatic cholangiocarcinoma

Seorin Jeong, Kyoungbun Lee, Xianyu Wen, Younghoon Kim, more

BMC Cancer > 2017 > 17 > 1 > 1-9

Background DNA methylation changes occurring in cancer cells are featured with both promoter CpG island hypermethylation and diffuse genomic hypomethylation. Long interspersed element-1 (LINE-1) is repeated in an interspersed manner with an estimated 500,000 copies per genome. LINE-1 has its CpG sites of the 5′ untranslated region methylated heavily in normal cells and undergoes demethylation in association...

article

Protein disulfide isomerase inhibition synergistically enhances the efficacy of sorafenib for hepatocellular carcinoma

Jae‐Kyung Won, Su Jong Yu, Chae Young Hwang, Sung‐Hwan Cho, more

Hepatology > 66 > 3 > 855 - 868

Sorafenib is the only approved targeted drug for hepatocellular carcinoma (HCC), but its effect on patients' survival gain is limited and varies over a wide range depending on pathogenetic conditions. Thus, enhancing the efficacy of sorafenib and finding a reliable predictive biomarker are crucial to achieve efficient control of HCCs. In this study, we utilized a systems approach by combining transcriptome...

article

A comprehensive study on in vitro and in vivo toxicological evaluation of Artemisia capillaris

Jun-Won Yun, Seung-Hyun Kim, Yun-Soon Kim, Ji-Ran You, more

Regulatory Toxicology and Pharmacology > 2017 > 88 > C > 87-95

Artemisia capillaris (AC) has been used as an alternative therapy in obesity, atopic dermatitis, and liver diseases through several biological activity including anti-steatotic, antioxidant, and anti-inflammatory activities. Despite its ethnomedicinal benefits, no sufficient background information is available about the long-term safety and genotoxicity of the AC extract. Therefore, the present study...

article

The correlation between poor prognosis and increased yes-associated protein 1 expression in keratin 19 expressing hepatocellular carcinomas and cholangiocarcinomas

KyuHo Lee, Kyoung-Bun Lee, Hae Yoen Jung, Nam-Joon Yi, more

BMC Cancer > 2017 > 17 > 1 > 1-9

Background The Hippo pathway plays a vital role in liver regeneration and development by determining cellular lineage and regulating cell proliferation and apoptosis. In this study, we aimed to assess the role of the Hippo pathway in hepatic carcinogenesis and morphogenesis by examining Yes-associated protein 1 (YAP1) expression in the spectrum of hepatic carcinomas based on cellular lineage. Methods...

article

Human umbilical cord-derived mesenchymal stem cells in acute liver injury: Hepatoprotective efficacy, subchronic toxicity, tumorigenicity, and biodistribution

Jun-Won Yun, Jae Hun Ahn, Euna Kwon, Seung-Hyun Kim, more

Regulatory Toxicology and Pharmacology > 2016 > 81 > C > 437-447

Umbilical cord-derived mesenchymal stem cells (UC-MSCs) therapy might be an alternative to liver transplantation for acute or chronic liver injury. The aim of this study was to evaluate the efficacy of human UC-MSCs on carbon tetrachloride (CCl₄)-induced acute liver injury. In addition, its toxicity, tumorigenicity, and biodistribution were determined. Significant hepatoprotective effects of hUC-MSCs...

article

In-vivo monitoring of development of cholangiocarcinoma induced with C. sinensis and N-nitrosodimethylamine in Syrian golen hamsters using ultrasonography and magnetic resonance imaging: a preliminary study

Hyunsik Woo, Joon Koo Han, Jung Hoon Kim, Sung-Tae Hong, more

European Radiology > 2017 > 27 > 4 > 1740-1747

Objectives The purpose of this study is to evaluate high-resolution ultrasound and magnetic resonance imaging (MRI) in monitoring of cholangiocarcinoma in the hamsters with C. sinensis infection and N-nitrosodimethylamine (NDMA). Materials and Methods Twenty-four male Syrian golden hamsters of were divided into four groups composed of five hamsters as control, five hamsters receiving 30 metacercariae...

article

Pre-clinical in vitro and in vivo safety evaluation of Cimicifuga heracleifolia

Jun-Won Yun, Ji-Ran You, Yun-Soon Kim, Eun-Young Cho, more

Regulatory Toxicology and Pharmacology > 2015 > 73 > 1 > 303-310

The rhizomes of Cimicifuga species, including Cimicifuga heracleifolia (CH), have been widely used as antipyretic, analgesic, and anti-inflammatory agents in oriental countries. However, information regarding its toxicity, especially long-term toxicity and genotoxicity, is limited. Therefore, we performed the subchronic toxicity and genotoxicity assays of the CH extract in accordance with the test...

article

Signal transducer and activator of transcription 3‐mediated CD133 up‐regulation contributes to promotion of hepatocellular carcinoma

Cheolhee Won, Byung‐Hak Kim, Eun Hee Yi, Kyung‐Ju Choi, more

Hepatology > 62 > 4 > 1160 - 1173

Enhanced expression of the cancer stem cell (CSC) marker, CD133, is closely associated with a higher rate of tumor formation and poor prognosis in hepatocellular carcinoma (HCC) patients. Despite its clinical significance, the molecular mechanism underlying the deregulation of CD133 during tumor progression remains to be clarified. Here, we report on a novel mechanism by which interleukin‐6/signal...

article

Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells

Dong Joon Kim, Young Soo Park, Min Gu Kang, Yeon-Mi You, more

Experimental Cell Research > 2015 > 336 > 1 > 119-129

Despite its wide use as a first-line therapeutic agent, gemcitabine has shown limited efficacy in advanced pancreatic cancer due to chemoresistance by as yet unidentified mechanisms. Our goal here was to identify molecular features involved in gemcitabine chemoresistance. Pyruvate kinase M2 (PKM2), a key enzyme of aerobic glycolysis, has recently emerged as an important therapeutic target for cancer...

article

Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype

Yul Ri Chung, Hyojin Kim, Soo Young Park, In Ae Park, more

Human Pathology > 2015 > 46 > 7 > 1027-1035

The aim of this study was to evaluate silent mating type information regulation 2 homolog 1 (SIRT1) expression levels by subtype and evaluate its predictive power of axillary lymph node metastasis (LNM) and its association with clinical outcome. A total of 427 patients diagnosed with invasive ductal carcinoma were chosen, immunohistochemical staining for SIRT1 expression was performed on tissue microarrays,...

article

Evaluation of subchronic (13week) toxicity and genotoxicity potential of vinegar-processed Genkwa Flos

Jun-Won Yun, Seung-Hyun Kim, Yun-Soon Kim, Ji-Ran You, more

Regulatory Toxicology and Pharmacology > 2015 > 72 > 2 > 386-393

Genkwa Flos (GF) is a well-known traditional medicine that is used to treat tumors and to relieve inflammation-related symptoms. GF tends to be taken in repeated doses for a long period of time, and although many reports on the toxicity of raw GF have led to a processing method to remove the toxicity, little information is currently available with regards to the toxic effects of subchronic exposure...

article

Comparative toxicity of silicon dioxide, silver and iron oxide nanoparticles after repeated oral administration to rats

Jun‐Won Yun, Seung‐Hyun Kim, Ji‐Ran You, Woo Ho Kim, more

Journal of Applied Toxicology > 35 > 6 > 681 - 693

Although silicon dioxide (SiO₂), silver (Ag) and iron oxide (Fe₂O₃) nanoparticles are widely used in diverse applications from food to biomedicine, in vivo toxicities of these nanoparticles exposed via the oral route remain highly controversial. To examine the systemic toxicity of these nanoparticles, well‐dispersed nanoparticles were orally administered to Sprague–Dawley rats daily over a 13‐week...

article

Genotoxicity and subchronic toxicity of Sophorae radix in rats: Hepatotoxic and genotoxic potential

Jeong-Hwan Che, Jun-Won Yun, Yun-Soon Kim, Seung-Hyun Kim, more

Regulatory Toxicology and Pharmacology > 2015 > 71 > 3 > 379-387

Although Sophorae radix (SR) has been traditionally used as a treatment for various clinical symptoms, a comprehensive investigation of its safety has not yet been carried out. Therefore, we present an evaluation of the toxicity of the SR extract that was performed according to the Organization for Economic Cooperation and Development test guidelines for subchronic toxicity and genotoxicity. In an...

article

Sonic hedgehog (SHH) and glioblastoma-2 (Gli-2) expressions are associated with poor jaundice-free survival in biliary atresia

Hae Yoen Jung, Jin Jing, Kyoung Bun Lee, Ja-June Jang

Journal of Pediatric Surgery > 2015 > 50 > 3 > 371-376

Biliary atresia (BA) causes biliary obstruction in neonates. Although the Kasai operation can successfully treat certain BA cases, many patients exhibit recurrent jaundice and secondary biliary cirrhosis requiring liver transplantation. Consequently, studies of the prognostic factors of the Kasai operation are needed. Accordingly, sonic hedgehog (SHH) pathway expression at the extrahepatic bile duct...

article

Clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma

Kyung-Hun Lee, Kyoung-Bun Lee, Tae-Yong Kim, Sae-Won Han, more

BMC Cancer > 2015 > 15 > 1 > 1-9

Background More knowledge about genetic and molecular features of cholangiocarcinoma is needed to develop effective therapeutic strategies. We investigated the clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma. Methods One hundred ninety-four patients with curatively resected intrahepatic cholangiocarcinoma were included in this study. Tumor tissue specimens...

article

Recurrence-associated pathways in hepatitis B virus-positive hepatocellular carcinoma

Bu-Yeo Kim, Dong Wook Choi, Seon Rang Woo, Eun-Ran Park, more

BMC Genomics > 2015 > 16 > 1 > 1-15

Background Despite the recent identification of several prognostic gene signatures, the lack of common genes among experimental cohorts has posed a considerable challenge in uncovering the molecular basis underlying hepatocellular carcinoma (HCC) recurrence for application in clinical purposes. To overcome the limitations of individual gene-based analysis, we applied a pathway-based approach for analysis...

article

Nuclear expression of phosphorylated TRAF2- and NCK-interacting kinase in hepatocellular carcinoma is associated with poor prognosis

Jing Jin, Hae Yoen Jung, Yuli Wang, Julie Xie, more

Pathology - Research and Practice > 2014 > 210 > 10 > 621-627

TRAF2- and NCK-interacting kinase (TNIK) is a member of the germinal center kinase family and a transcription factor 4 (TCF4) interactor is recruited to promoters of Wnt target genes via phosphorylation of the TCF/β-catenin complex. The aim of this study was to evaluate the TNIK, the active form of TNIK (p-TNIK), and β-catenin expression in hepatocellular carcinoma (HCC), and to identify the prognostic...

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HEPATOCELLULAR CARCINOMA (10)
PROGNOSIS (9)
APOPTOSIS (8)
CHOLANGIOCARCINOMA (7)
SUBCHRONIC (6)
GENOTOXICITY (5)
TOXICITY (5)
HEPATIC STELLATE CELL (3)
HEPATOBLASTOMA (3)
HEPATOTOXICITY (3)
BILE ACID (2)
BIODISTRIBUTION (2)
CELL CYCLE (2)
FIBROSIS (2)
HEPATIC PROGENITOR CELLS (2)
HEPATIC STEATOSIS (2)
HSP70 (2)
IMMUNOHISTOCHEMISTRY (2)
INVASION (2)
LIVER (2)
METASTASIS (2)
NICOTINAMIDE (2)
SURVIVAL ANALYSIS (2)
TRADITIONAL MEDICINE (2)
AFLATOXIN B 1 (1)
2-(ALLYLTHIO)PYRAZINE (1)
ACUTE (1)
ACUTE LIVER TOXICITY (1)
ADRENOMEDULLIN (1)
AKT (1)
AMES (1)
ANEMIA (1)
ANTI-FIBROSIS (1)
ARSENIC TRIOXIDE (1)
ARTEMISIA CAPILLARIS (1)
ASPERGILLUS TERREUS (1)
AUTOIMMUNE HEPATITIS (1)
AUTORADIOGRAPHY (1)
B7‐H1 (1)
BILIARY ATRESIA (1)
BILIARY INTRAEPITHELIAL NEOPLASIA (1)
BILIARY TRACT CANCER (1)
BIOPSY (1)
BREAST CANCER (1)
CANCER CAUSATION (1)
CARBON TETRACHLORIDE (CCL4) (1)
CCL4 THIOACETAMIDE RATS LIVER CIRRHOSIS CELL CYCLE-RELATED PROTEINS (1)
CDK4 (1)
CELL CYCLE-RELATED PROTEINS (1)
CELL PROLIFERATION (1)
CELL REPLICATION (1)
CHEMOTHERAPY RESISTANCE (1)
CHOLESTASIS (1)
CIMICIFUGA HERACLEIFOLIA (1)
CK19 (1)
CLINICAL TRIAL (1)
CLO TEST (1)
CLONORCHIASIS (1)
COMBINED HEPATOCELLULAR AND CHOLANGIOCARCINOMA (1)
CONCANAVALIN A (1)
CPG ISLAND (1)
CYCLOOXYGENASE-2 (1)
CYTOKERATIN 19 (1)
DASL CHIP ASSAY (1)
DETECTION (1)
DICHLOROMETHANE (1)
DIETHYLNITROSAMINE (1)
DIETHYLNITROSAMINE (DEN) (1)
DIFFERENTIAL DIAGNOSIS (1)
DNA ADDUCT (1)
DNA CHIP (1)
DNA HYPERMETHYLATION (1)
DNA HYPOMETHYLATION (1)
DUCTULAR REACTION (1)
DYSPLASTIC NODULES (1)
EPCAM (1)
EPITHELIAL-MESENCHYMAL TRANSITION (1)
ETHYLBENZENE (1)
EWING’S SARCOMA/PERIPHERAL PRIMITIVE NEUROECTODERMAL TUMOR (1)
F-18-FDG (1)
F-18-FLUOROERYTHRONITROIMIDAZOLE (1)
FAS (1)
FAS LIGAND (1)
FAS-ASSOCIATED PHOSPHATASE-1 (1)
FERMENTED FOOD (1)
FISH (1)
FITC (1)
FLUORESCENCE (1)
FUNCTIONAL FOOD (1)
G1 CHECK POINT CELL CYCLE PROTEINS (1)
G1/S PHASE REGULATORY PROTEIN (1)
GALACTOSE (1)
GASTRIC ADENOCARCINOMA (1)
GASTRIC CANCER (1)
GEMCITABINE (1)
GENE EXPRESSION SIGNATURE (1)
GLIOBLASTOMA-2 (GLI-2) (1)
GLUTATHIONE S-TRANSFERASE (1)
GS (1)
HAMSTER (1)
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Elsevier (40)
Springer (19)
Wiley (11)
ACS (1)

Journal

Regulatory Toxicology and Pharmacology (6)
Human Pathology (5)
BMC Cancer (3)
Biochemical and Biophysical Research Communications (3)
Journal of Hepatology (3)
Virchows Archiv (3)
Cancer Letters (2)
Experimental and Toxicologic Pathology (2)
FEBS Letters (2)
Gastroenterology (2)
Hepatology (2)
Pathology - Research and Practice (2)
The American Journal of Pathology (2)
Toxicology Letters (2)
APMIS (1)
Abdominal Radiology (1)
Annals of Diagnostic Pathology (1)
Annals of Nuclear Medicine (1)
Annals of Surgical Oncology (1)
Archives of Pharmacal Research (1)
BMC Complementary and Alternative Medicine (1)
BMC Genomics (1)
Cancer Genetics and Cytogenetics (1)
Cancer Science (1)
Chemico-Biological Interactions (1)
Clinical Transplantation (1)
Environmental Science & Technology (1)
European Radiology (1)
Experimental Cell Research (1)
Hepatology Research (1)
Japanese Journal of Cancer Research (1)
Journal of Applied Toxicology (1)
Journal of Cellular Physiology (1)
Journal of Gastroenterology (1)
Journal of Hepato-Biliary-Pancreatic Sciences (1)
Journal of Pediatric Surgery (1)
Journal of Pharmacy and Pharmacology (1)
Journal of Surgical Research (1)
Liver International (1)
Molecular & Cellular Toxicology (1)
Pediatric Radiology (1)
The Journal of Molecular Diagnostics (1)
Tissue Engineering and Regenerative Medicine (1)
Toxicology and Applied Pharmacology (1)
Transplant International (1)
World Journal of Surgery (1)
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INFONA - science communication portal

Search results for: Ja-June Jang

Assessment of acute, 14-day, and 13-week repeated oral dose toxicity of Tiglium seed extract in rats

Nicotinamide suppresses cell growth by G1-phase arrest and induces apoptosis in intrahepatic cholangiocarcinoma

Absence of subchronic oral toxicity and genotoxicity of rice koji with Aspergillus terreus

Tumoral LINE-1 hypomethylation is associated with poor survival of patients with intrahepatic cholangiocarcinoma

Protein disulfide isomerase inhibition synergistically enhances the efficacy of sorafenib for hepatocellular carcinoma

A comprehensive study on in vitro and in vivo toxicological evaluation of Artemisia capillaris

The correlation between poor prognosis and increased yes-associated protein 1 expression in keratin 19 expressing hepatocellular carcinomas and cholangiocarcinomas

Human umbilical cord-derived mesenchymal stem cells in acute liver injury: Hepatoprotective efficacy, subchronic toxicity, tumorigenicity, and biodistribution

In-vivo monitoring of development of cholangiocarcinoma induced with C. sinensis and N-nitrosodimethylamine in Syrian golen hamsters using ultrasonography and magnetic resonance imaging: a preliminary study

Pre-clinical in vitro and in vivo safety evaluation of Cimicifuga heracleifolia

Signal transducer and activator of transcription 3‐mediated CD133 up‐regulation contributes to promotion of hepatocellular carcinoma

Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells

Distinctive role of SIRT1 expression on tumor invasion and metastasis in breast cancer by molecular subtype

Evaluation of subchronic (13week) toxicity and genotoxicity potential of vinegar-processed Genkwa Flos

Comparative toxicity of silicon dioxide, silver and iron oxide nanoparticles after repeated oral administration to rats

Genotoxicity and subchronic toxicity of Sophorae radix in rats: Hepatotoxic and genotoxic potential

Sonic hedgehog (SHH) and glioblastoma-2 (Gli-2) expressions are associated with poor jaundice-free survival in biliary atresia

Clinical and pathological significance of ROS1 expression in intrahepatic cholangiocarcinoma

Recurrence-associated pathways in hepatitis B virus-positive hepatocellular carcinoma

Nuclear expression of phosphorylated TRAF2- and NCK-interacting kinase in hepatocellular carcinoma is associated with poor prognosis

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