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Abstract Hereditary cerebral haemorrhage with amyloidosis, Dutch type (HCHWA-D), caused by a mutation at codon 693 in the amyloid precursor protein (PP) gene, is clinically characterised by haemorrhagic strokes and dementia. The secreted forms PP751 and PP770 are identical to protease nexin II (PNII), which is a potent inhibitor of intrinsic blood coagulation factor XIa in vitro. We investigated the...
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