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A chronic neuron loss is the cardinal pathology in Alzheimer disease (AD), but it is still not understood why most neurons in AD brain do not accomplish apoptosis even though they are actually exposed to an environment with enriched proapoptotic factors. Protein phosphatase-2A inhibitor-2 (I 2PP2A ), an endogenous PP2A inhibitor, is significantly increased in AD brain, but the role of...
The activity of protein phosphatase-2A (PP-2A) is significantly suppressed in the brain of Alzheimer's disease (AD) patients, but the mechanism is not understood. Here, we found an in vivo association of glycogen synthase kinase 3β (GSK-3β) with inhibitor-2 of PP-2A (I 2PP-2A ). The activation of GSK-3 resulted in accumulation of I 2PP-2A with concomitant suppression of PP-2A...
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