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Objectives. To determine whether augmented activation (degranulation) of platelets might contribute to the association between higher concentrations of fibrinogen and risk of myocardial infarction, we characterized adenosine diphosphate (ADP)-induced expression of P-selectin by platelets in whole blood as a function of this exposure to selected concentrations of fibrinogen.Background. An increased...
Background: Circulating cardiac troponin I (cTnI) is a sensitive biochemical marker for detection of myocardial cell damage and has been shown to be related to adverse short term prognosis in patients (pts) with acute coronary syndrome (ACS). We investigated prospectively the value of rapid bedside cTnI testing in n = 773 pts with acute chest pain but without ST-elevation in the electrocardiogram...
Plasminogen activators (PAs, tissue type [t-PA] and urokinase type [u-PA]) and their primary inhibitor (type 1 [PAI-1]) may modulate progression of atherogenesis by facilitating accumulation and degradation of extracellular matrix. In this study, we determined the tissue content of PAs and PAI-1 in paired samples of normal and atherosclerotic arteries from the same patient. The tissue obtained during...
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