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The angiotensin II type 1 receptor (AT1R) blocker (ARB) Losartan has cardioprotective effects during ischemia–reperfusion injury and inhibits reperfusion arrhythmias –effects that go beyond the benefits of lowering blood pressure. The renin–angiotensin and kallikrein–kinin systems are intricately connected and some of the cardioprotective effects of Losartan are abolished by blocking the bradykinin...
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