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Depth-resolved intravascular photoacoustic imaging has been shown to successfully image lipid in atherosclerotic plaques. During IVPA imaging, the level of laser irradiation and corresponding thermal dose depends on the imaging parameters (number of A-lines per frame, frame rate, pullback speed, pulse energy). It is unclear what level of laser irradiation will cause inadvertent tissue damage — the...
The pharmaceutical development of new chemical entities can be hampered by their solubility and/or dissolution limitations. Currently, these properties are characterised mostly during in vivo pre-clinical studies. The development of appropriate in vitro methods to study the solubility and dissolution properties in preclinical species would lead to a significant reduction or replacement of the animal...
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