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The IKK/NF-κB signalling pathway plays a predominant role in the regulation of inflammation and apoptosis in spinal cord injury (SCI). We have previously demonstrated that targeting of the IKK/NF-κB pathway improved the recovery of locomotor function by reducing the infiltration of inflammatory cells and apoptosis after SCI in rats. Recently, the neuroprotective effects of butein have been shown via...
IKK/NF-κB pathway is a principal player in the regulation of inflammation and apoptosis in spinal cord injury (SCI). We have previously shown that BMS-345541, a selective inhibitor of IKK, could inhibit NF-κB activation and ameliorate the motor function of hind limbs in rats after SCI. However its neuroprotective mechanism in SCI is still unclear. In this study, we investigated the neuroprotective...
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