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ASPP2 regulates cell polarity and cell–cell adhesion by binding to, and co-localizing with PAR3 at tight junctions. Here we show a novel role of ASPP2 in suppressing gastric cancer (GC) invasiveness. Immunoprecipitation and immunofluorescence analyses showed that ASPP2 promoted the recruitment of PAR3 to cell–cell junctions in GC cells. Diminished expression of ASPP2 and loss of junctional PAR3 localization...
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