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We examined the role of gastric mucosal bloodflow, lipid peroxidation, and neutrophil accumulationmediated by platelet-activating factor in the protectiveeffect of rebamipide against gastric mucosal injury in rats. The intravenous injection ofplatelet-activating factor induced hyperemia andhemorrhagic erosions in rat stomachs. Rebamipide did notaffect the decrease in the gastric mucosal blood flow...
The effect of roxatidine, a histamine H 2 -receptor antagonist, on acute gastric mucosal injury induced by aspirin-HCl was investigated from the standpoint of lipid peroxidation and neutrophil accumulation in rats. Acute mucosal injury was produced on the rat stomach by intragastric administration of aspirin and HCl. Pretreatment with roxatidine at doses of 3 and 10 mg/kg significantly reduced...
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