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Detection and quantitation of interferon-gamma (IFN-γ) in blood is of vital importance for diagnosis of latent tuberculosis. The authors describe an electrochemical aptasensor for IFN-γ that is based on a triple-helix molecular switch (THMS). The combination of a THMS with amperometry makes the sensor selective, sensitive and fast (50 min). In the presence of IFN-γ, the structure of the THMS is disassembled...
The authors describe an electrochemical aptasensing platform for the determination of Pb(II) ions. The assay is based on the use of gold nanoparticles (AuNPs) (that facilitate electron transfer), the enzyme exonuclease III (Exo III; assisting signal amplification), and a hairpin structured complementary strand of an aptamer that prevents binding of AuNPs to the surface of the sensor electrode in the...
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