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Failing hearts undergo electrical and structural remodeling, setting the stage for malignant arrhythmias. Increased dispersion of repolarization has been suggested to underlie increased arrhythmogenesis in human heart failure (HF). Recent experimental studies have shown that transmural dispersion of repolarization (TDR) decreases in failing hearts, while others have observed an increase in similar...
Failing hearts undergo electrical and structural remodeling, setting the stage for malignant arrhythmias. Specifically, failing hearts show enhanced late Na+ current (INaL) and cellular uncoupling. In the present study, the effects of these changes on transmural dispersion of repolarization (TDR), on action potential duration (APD) gradient and on the safety factor for conduction (SF) were simulated...
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