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The development of opioid addiction involves DNA methylation. Accordingly, the DNA demethylation, induced by ten‐eleven translocation (Tet) enzymes, may represent a novel approach to prevent opioid addiction. The present study examined the role of TET1 and TET3 in the development of morphine‐seeking behavior in rats. We showed that 1 day of morphine self‐administration (SA) training upregulated TET3...
Drug‐reinforced excessive operant responding is one fundamental feature of long‐lasting addiction‐like behaviors and relapse in animals. However, the transcriptional regulatory mechanisms responsible for the persistent drug‐specific (not natural rewards) operant behavior are not entirely clear. In this study, we demonstrate a key role for one of the de novo DNA methyltransferase, DNMT3a, in the acquisition...
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