Search results for: Mario García-Carrasco

Items from 1 to 20 out of 34 results

article

Histamine induces intracellular Ca²⁺ oscillations and nitric oxide release in endothelial cells from brain microvascular circulation

Roberto Berra‐Romani, Pawan Faris, Giorgia Pellavio, Matteo Orgiu, more

Journal of Cellular Physiology > 235 > 2 > 1515 - 1530

The neuromodulator histamine is able to vasorelax in human cerebral, meningeal and temporal arteries via endothelial histamine 1 receptors (H₁Rs) which result in the downstream production of nitric oxide (NO), the most powerful vasodilator transmitter in the brain. Although endothelial Ca ²⁺ signals drive histamine‐induced NO release throughout the peripheral circulation, the mechanism by which histamine...

article

25‐Hydroxyvitamin D concentrations and risk of metabolic syndrome in systemic lupus erythematosus women

Mario García‐Carrasco, Claudia Mendoza‐Pinto, Miriam Cabrera‐Jiménez, Pamela Munguía‐Realpozo, more

International Journal of Rheumatic Diseases > 22 > 11 > 2067 - 2072

Objective A protective function of vitamin D in metabolic syndrome (MetS) has been described. The objective of the present study was to examine the relationship between serum 25‐hydroxyvitamin D (25(OH)D) concentrations and MetS in non‐diabetic systemic lupus erythematosus (SLE) women. Methods Cross‐sectional analyses of the relationship between concentrations of 25(OH)D, MetS, and its components...

article

Functional gastrointestinal disorders in women with systemic lupus erythematosus: A case‐control study

Mario García‐Carrasco, Claudia Mendoza‐Pinto, Pamela Munguía‐Realpozo, Fabiola Méndez‐Valderrabano, more

Neurogastroenterology & Motility > 31 > 11 > n/a - n/a

Background Systemic lupus erythematosus (SLE) is an autoimmune disease with multisystemic involvement. Gastrointestinal (GI) manifestations are frequent but functional gastrointestinal disorders (FGIDs) have scarcely been studied in SLE. To determine the prevalence of FGIDs and their potential risk factors in SLE female patients vs controls. Methods Systemic lupus erythematosus patients meeting...

article

Clinical relevance of monitoring serum adalimumab levels in axial spondyloarthritis

José Miguel Senabre Gallego, Jose Rosas, Mariana Marco-Mingot, José Alberto García-Gómez, more

Rheumatology International > 2019 > 39 > 5 > 841-849

Our aim was to assess the relationship between serum adalimumab levels, anti-drug antibodies (ADA) and disease activity in patients with axial spondylarthritis (SpA). We have carried out a single-centre cross-sectional study. adalimumab and ADA levels were analysed with ELISA and correlated with SpA activity using BASDAI and ASDAS scores. Adalimumab cut-off value was calculated to discriminate inactive...

article

Role of Infectious Diseases in the Antiphospholipid Syndrome (Including Its Catastrophic Variant)

Claudia Mendoza-Pinto, Mario García-Carrasco, Ricard Cervera

Current Rheumatology Reports > 2018 > 20 > 10 > 1-7

Purpose of Review The antiphospholipid syndrome (APS) is characterized by the development of thrombotic events and pregnancy morbidity in the presence of antiphospholipid antibodies (aPL). An infectious etiology for this syndrome has been postulated. The present review is aimed to summarize recent evidence about the role of infections and vaccines in the pathogenesis of the APS (including its catastrophic...

article

Clinical relevance of P-glycoprotein activity on peripheral blood mononuclear cells and polymorphonuclear neutrophils to methotrexate in systemic lupus erythematosus patients

Mario García-Carrasco, Claudia Mendoza-Pinto, Salvador Macías-Díaz, Ivet Etchegaray-Morales, more

Clinical Rheumatology > 2017 > 36 > 10 > 2267-2272

To elucidate the relationship between P-glycoprotein activity on peripheral blood leukocytes of systemic lupus erythematosus (SLE) patients with lupus arthritis and the clinical response to methotrexate. An observational study was made in patients with SLE according to ACR criteria 1997 who had arthralgia and arthritis and received methotrexate for ≥3 months. Methotrexate responders and non-responders...

article

Vitamin D and Sjögren syndrome

Mario Garcia-Carrasco, Erick Alejandro Jiménez-Herrera, Jose Luis Gálvez-Romero, Luis Vázquez de Lara, more

Autoimmunity Reviews > 2017 > 16 > 6 > 587-593

The immunomodulatory effects of vitamin D have been extensively studied in the context of autoimmunity. Multiple studies have demonstrated a high prevalence of vitamin D deficiency in autoimmune diseases. Recently, a possible protective role of vitamin D in autoimmunity has been described; however, this function remains controversial. Few studies have investigated the role of vitamin D in patients...

article

Incidence of Vertebral Fractures in Women with Systemic Lupus Erythematosus After 8 Years of Follow-Up

Mario García-Carrasco, Claudia Mendoza-Pinto, María de la Luz León-Vázquez, Socorro Méndez-Martínez, more

Calcified Tissue International > 2017 > 101 > 3 > 291-299

The aim of this study was to evaluate possible associations between potential risk factors and the occurrence of established vertebral fractures (VF) in Mexican patients with systemic lupus erythematosus (SLE). Consecutive patients with SLE were enrolled in a prospective, observational study from 2006 to 2015. Information on potential risk factors, including demographics, clinical data, and bone mineral...

article

Vitamin D Insufficiency and Deficiency in Mexican Patients With Systemic Lupus Erythematosus: Prevalence and Relationship With Disease Activity

Mario García-Carrasco, Claudia Mendoza-Pinto, Ivet Etchegaray-Morales, Pamela Soto-Santillán, more

Reumatolog�a Cl�nica (English Edition) > 2017 > 13 > 2 > 97-101

To determine and compare the prevalence of vitamin D insufficiency and deficiency in patients with systemic lupus erythematosus (SLE) with and without disease activity.We made a comparative, observational, cross-sectional, prospective study of 137 women with SLE according to American College of Rheumatology criteria. Patients with chronic kidney disease, cancer, hyperparathyroidism, pregnancy, and...

article

Vitamin D and cardiovascular disease in patients with systemic lupus erythematosus

Mario García-Carrasco, Jose Luis Romero-Galvez

Reumatolog�a Cl�nica (English Edition) > 2016 > 12 > 5 > 241-243

article

Vitamin D and autoimmune rheumatic disease

Mario García-Carrasco, José Luis Gálvez Romero

Reumatologia clinica (English Edition) > 2015 > 11 > 6 > 333-334

article

Diagnosis and classification of Susac syndrome

Mario García-Carrasco, Claudia Mendoza-Pinto, Ricard Cervera

Autoimmunity Reviews > 2014 > 13 > 4-5 > 347-350

Susac syndrome (SS) is an autoimmune disease characterized by the clinical triad of encephalopathy, branch retinal artery occlusions and neuro-sensorial hearing loss; it is due to a microangiopathy affecting the precapillary arterioles of the brain, retina and inner ear. SS is characterized by typical radiological features on magnetic resonance imaging (MRI) which, together with clinical symptoms,...

article

Immunopathogenesis of vitiligo

Manuel Sandoval-Cruz, Mario García-Carrasco, Renán Sánchez-Porras, Claudia Mendoza-Pinto, more

Autoimmunity Reviews > 2011 > 10 > 12 > 762-765

Vitiligo is a common depigmenting disorder which may have devastating psychological and social consequences and is characterized by the presence of circumscribed white macules in the skin due to the destruction of melanocytes in the epidermis. Various hypotheses have been proposed to explain the pathomechanisms involved in this disease, and studies have shown the participation of autoimmune processes...

article

Susac's syndrome: An update

Mario García-Carrasco, César Jiménez-Hernández, Mario Jiménez-Hernández, Stephanie Voorduin-Ramos, more

Autoimmunity Reviews > 2011 > 10 > 9 > 548-552

Susac's syndrome is an infrequent neurological disorder characterized by the clinical triad of encephalopathy, hearing loss, and branch retinal artery occlusions. Its pathophysiology is not entirely clear, although it is now thought that it is most probably an immune-mediated endotheliopathy that affects the microvasculature of the brain, retina, and inner ear. An early diagnosis is important as treatment...

article

Etiopathogenesis of Behcet's disease

Claudia Mendoza-Pinto, Mario García-Carrasco, Mario Jiménez-Hernández, Cesar Jiménez Hernández, more

Autoimmunity Reviews > 2010 > 9 > 4 > 241-245

Bechet's disease (BD) is an inflammatory, multi systemic disease with spontaneous remissions and relapses similar to various autoimmune diseases. BD leads to organ damage, including the eyes, skin, joints, etc., which produces various clinical manifestations. The central histopathologic characteristic is systemic vasculitis with perivascular inflammatory infiltrates. The etiopathogenesis is unknown,...

article

P-glycoprotein activity in renal clear cell carcinoma

Elena Soto-Vega, Carlos Arroyo, Yvonne Richaud-Patin, Mario García-Carrasco, more

Urologic Oncology: Seminars and Original Investigations > 2009 > 27 > 4 > 363-366

The mechanism by which renal cancer patients show poor response to chemotherapy has not been well understood. The aim of this study was to evaluate the functional activity of P-glycoprotein (P-gp) in renal clear cell carcinoma (RCCC) and its possible role in chemotherapy resistance.We studied 11 patients who underwent radical nephrectomy due to RCCC; from each patient we obtained a sample from the...

article

Use of rituximab in patients with systemic lupus erythematosus: An update

Mario García-Carrasco, Mario Jiménez-Hernández, Ricardo O. Escárcega, Claudia Mendoza-Pinto, more

Autoimmunity Reviews > 2009 > 8 > 4 > 343-348

Systemic lupus erythematosus (SLE) is a chronic, occasionally life threatening, multisystem disorder. Patients suffer from a wide group of symptoms and have a variable prognosis that depends of the severity and type of organ involvement. The clinical manifestations include fever, skin lesions, arthritis, neurologic, renal, cardiac, and pulmonary disease. The pathogenesis of this serious multisystem...

article

Infections and the Antiphospholipid Syndrome

Mario García-Carrasco, Claudio Galarza-Maldonado, Claudia Mendoza-Pinto, Ricardo O. Escarcega, more

Clinical Reviews in Allergy & Immunology > 2009 > 36 > 2-3 > 104-108

Currently, the origin of autoimmune diseases is considered to be multifactorial. Genetic predisposition, immune system malfunction or even backfire, hormonal regulation, and environmental factors, i.e. infections, all play important roles in the pathogenesis of autoimmune diseases such as the antiphospholipid syndrome (APS). New drugs and strategies aimed at preventing infections could further improve...

article

Risks factors for low bone mineral density in pre-menopausal Mexican women with systemic lupus erythematosus

Claudia Mendoza-Pinto, Mario García-Carrasco, Hilda Sandoval-Cruz, Ricardo O. Escárcega, more

Clinical Rheumatology > 2009 > 28 > 1 > 65-70

The aim of this study was to determine the prevalence and risk factors for low bone mineral density (BMD) in women with systemic lupus erythematosus (SLE). A cross-sectional study was conducted among 100 pre-menopausal patients with SLE. Patients were evaluated using a questionnaire about the following variables: age, disease duration, disease activity, chronic disease damage, cumulative corticosteroid...

article

Risk factors of vertebral fractures in women with systemic lupus erythematosus

Claudia Mendoza-Pinto, Mario García-Carrasco, Hilda Sandoval-Cruz, Margarita Muñoz-Guarneros, more

Clinical Rheumatology > 2009 > 28 > 5 > 579-585

The aim of the current study was to analyze the role of traditional and systemic lupus erythematosus (SLE)-related risk factors in the development of vertebral fractures. A cross-sectional study was performed in women with SLE attending a single center. A vertebral fracture was defined as a reduction of at least 20% of vertebral body height. Two hundred ten patients were studied, with median age of...

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Search results for: Mario García-Carrasco

Histamine induces intracellular Ca²⁺ oscillations and nitric oxide release in endothelial cells from brain microvascular circulation

25‐Hydroxyvitamin D concentrations and risk of metabolic syndrome in systemic lupus erythematosus women

Functional gastrointestinal disorders in women with systemic lupus erythematosus: A case‐control study

Clinical relevance of monitoring serum adalimumab levels in axial spondyloarthritis

Role of Infectious Diseases in the Antiphospholipid Syndrome (Including Its Catastrophic Variant)

Clinical relevance of P-glycoprotein activity on peripheral blood mononuclear cells and polymorphonuclear neutrophils to methotrexate in systemic lupus erythematosus patients

Vitamin D and Sjögren syndrome

Incidence of Vertebral Fractures in Women with Systemic Lupus Erythematosus After 8 Years of Follow-Up

Vitamin D Insufficiency and Deficiency in Mexican Patients With Systemic Lupus Erythematosus: Prevalence and Relationship With Disease Activity

Vitamin D and cardiovascular disease in patients with systemic lupus erythematosus

Vitamin D and autoimmune rheumatic disease

Diagnosis and classification of Susac syndrome

Immunopathogenesis of vitiligo

Susac's syndrome: An update

Etiopathogenesis of Behcet's disease

P-glycoprotein activity in renal clear cell carcinoma

Use of rituximab in patients with systemic lupus erythematosus: An update

Infections and the Antiphospholipid Syndrome

Risks factors for low bone mineral density in pre-menopausal Mexican women with systemic lupus erythematosus

Risk factors of vertebral fractures in women with systemic lupus erythematosus

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