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Trefoil factor family (TFF)-domain peptides 1–3 are mucin-associated molecules, largely found in epithelia of gastro-intestinal tissues. Structurally similar, resistant to enzymatic degradation, they are up-regulated around areas of epithelial damage such as ulcers. Transgenic expression or exogenous peptide ameliorates or prevents gastric mucosal damage due to indomethacin and some are rapidly up-regulated...
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