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Ion channels expressed in monocytes/macrophages have been tightly attached to atherosclerosis by coupling cellular function with electrical activity. However, the function of ATP-sensitive potassium channels (K ATP ) in atherosclerosis has not been investigated directly. This study was performed to explore its role in atherosclerosis.ApoE −/− mice with collar placement and Ad5-CMV...
Extracellular acidic pH activated chloride channels (I Cl,acid ) have been characterized in HEK 293 cells and mammalian cardiac myocytes. This study was designed to evaluate the expression of I Cl,acid in RAW264.7 monocytic-macrophage and human peripheral monocytes and to investigate the effect of simvastatin on I Cl,acid . In two kinds of cells, the activation and deactivation...
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