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Schistosomes cause significant morbidity and mortality. In this article, we discuss recent findings regarding how different schistosome species infect and manipulate immune responses in their hosts through the evolution and use of different protease classes. The advent of transgenic schistosomes is explored in relation to the biology of these important molecules.
Understanding the molecular basis of parasitism, particularly that linked to human disease, is one of the most important frontiers in biology. A major impediment to the direct analysis of the genes of nematode and platyhelminth parasites is the practical impossibility of investigating their function with any of the genetic methods used so effectively for many multicellular model organisms and unicellular...
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