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Introduction: Multiple Sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS) which can be studied in experimental allergic encephalomyelitis (EAE), the autoimmune model of MS. Chronic relapsing EAE (CREAE) may be induced in Biozzi ABH mice following immunisation with spinal cord homogenate (SCH) in which demyelination in the CNS is marked in the relapse phase...
Introduction: The small heat shock protein αB-crystallin is expressed in active multiple sclerosis (MS) lesions and has been shown to be the immunodominant T cell antigen in MS-affected myelin (van Noort et al 1995 Nature 375: 798-801). The objective of this study was to determine the encephalitogenicity and immunodominant T-cell epitopes of αB-crystallin in Biozzi ABH (H-2A g7 ) mice...
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