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Ocular neovascular disorders, such as diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity and corneal neovascularization, are the most common causes of blindness and vision loss. The abnormal growth of new blood vessels in the avascular compartments of the eye, vascular leakage and hemorrhage can affect visual acuity. Different ocular neovascular disorders have the characteristic...
Benzalkonium Chloride (BAC) is commonly used in eyedrops. Although the cytotoxicity of BAC has been reported, the mechanism underlying its toxic effect has not been elucidated. The present study investigated the role of the Wnt signaling pathway in the cytotoxicity of BAC in corneal epithelial cells and in the rat cornea. We demonstrated that phosphorylation of β-catenin, a downstream effector of...
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