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Stromal interaction molecule 1 (STIM1) is an endoplasmic reticulum (ER)-membrane associated Ca 2+ sensor which activates store-operated Ca 2+ entry (SOCE). The homologue, STIM2 possesses a high sequence identity to STIM1 (∼61%), while its role in SOCE seems to be distinct from that of STIM1. In order to understand the underlying mechanism for the functional differences between STIM1...
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