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Two charged Thioflavin T (ThT) derivatives, referred to here as ICT2 and ICT3, showed higher fluorescence response, association constants and the blue-shifted emission maxima in the presence of lysozyme fibrils compared to insulin aggregates. In turn, the other two ThT derivatives, ICT4 and ICT5, possessed much weaker sensitivity to amyloid fibrils. Furthermore, a direct correlation was found between...
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