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Trastuzumab has shown positive results in many patients with metastatic HER2-positive breast cancer, but it is less effective for controlling metastases in the CNS, which remains a site of relapse. The poor prognosis for patients with brain metastases is thought to be largely due to the presence of the blood‐brain barrier (BBB) that prevents delivery of most drugs to the CNS and to the heterogeneous...
Several studies have demonstrated that focused ultrasound (FUS) in the presence of microbubbles is able to temporarily disrupt the blood-brain barrier (BBB) and deliver drugs to the central nervous system. While magnetic resonance-guided FUS (MRgFUS) treatments have shown promising results in targeted drug delivery, one question still remains how much the blood vessel permeability can be enhanced...
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