Wyniki wyszukiwania dla: Stefan Sjöberg

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Higher CSF/serum free‐T4 ratio is associated with improvement of quality of life during treatment with L‐thyroxine

Anders Funkquist, Birger Wandt, Kaj Blennow, Henrik Zetterberg, więcej

Journal of Neuroendocrinology > 35 > 5 > n/a - n/a

Up to 20% of individuals with primary hypothyroidism treated with L‐thyroxine still suffer from severe symptoms. These are supposedly brain derived and involve both cognitive and emotional domains. Previously, no consistent relationship has been found between thyroid hormones (TH) or TSH levels in blood and quality of life (QoL). Recently, we reported an association between cerebrospinal fluid (CSF)/serum...

artykuł

Effect of Liraglutide on Times in Glycaemic Ranges as Assessed by CGM for Type 2 Diabetes Patients Treated With Multiple Daily Insulin Injections

Sheyda Sofizadeh, Henrik Imberg, Arndís F. Ólafsdóttir, Magnus Ekelund, więcej

Diabetes Therapy > 2019 > 10 > 6 > 2115-2130

Introduction The effects of the GLP-1 analogue liraglutide on time in hypoglycaemia, time in hyperglycaemia, and time in range for type 2 diabetes patients initially treated with multiple daily insulin injections (MDI) were investigated. Variables associated with hypoglycaemia in the current population were also identified. Methods Analyses were based on data from a previously performed double-blind,...

artykuł

Collective empowerment: A comparative study of community work in Mumbai and Stockholm

Stefan Sjöberg, Komalsingh Rambaree, Bipin Jojo

International Journal of Social Welfare > 24 > 4 > 364 - 375

Mumbai and Stockholm are worlds apart in terms of public services, infrastructures and standard of living. However, both cities have known common problems of social exclusion and marginalisation related to neo‐liberal globalisation. Social workers are facing similar challenges regarding collective empowerment as a strategy for community work. This comparative study explored how collective empowerment...

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Large inclusion constants of β-cyclodextrin with carborane derivatives

Rimantas Vaitkus, Stefan Sjöberg

Journal of Inclusion Phenomena and Macrocyclic Chemistry > 2011 > 69 > 3-4 > 393-395

Complexation of some o-, m- and p-carborane derivatives with β-cyclodextrin was investigated using phenolphthalein in pH 10.5 (0.05 mol dm⁻³) borate buffer. Some carborane derivatives indicated large inclusion constants K_ass > 1 × 10⁵dm³ mol⁻¹.

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Nuclisome: a novel concept for radionuclide therapy using targeting liposomes

Amelie Fondell, Katarina Edwards, Ludger M. Ickenstein, Stefan Sjöberg, więcej

European Journal of Nuclear Medicine and Molecular Imaging > 2010 > 37 > 1 > 114-123

Purpose For the treatment of cancer, the therapeutic potential of short-range, low-energy Auger-electron emitters, such as ¹²⁵I, is getting progressively wider recognition. The potency of Auger-electron emitters is strongly dependent on their location in close vicinity to DNA. We have developed a new two-step targeting strategy to transport ¹²⁵I into cancer-cell nuclei using PEG-stabilized tumour-cell...

artykuł

Influence of valency and labelling chemistry on in vivo targeting using radioiodinated HER2-binding Affibody molecules

Vladimir Tolmachev, Eskender Mume, Stefan Sjöberg, Fredrik Y. Frejd, więcej

European Journal of Nuclear Medicine and Molecular Imaging > 2009 > 36 > 4 > 692-701

Purpose HER2 is a transmembrane tyrosine kinase, which is overexpressed in a number of carcinomas. The Affibody molecule Z_HER2:342 is a small (7 kDa) affinity protein binding to HER2 with an affinity of 22 pM. The goal of this study was to evaluate the use of ((4-hydroxyphenyl)ethyl)maleimide (HPEM) for radioiodination of Z_HER2:342 and to compare the targeting properties of monomeric and dimeric forms...

artykuł

A novel 125I-labeled daunorubicin derivative for radionuclide-based cancer therapy

Ludger M. Ickenstein, Katarina Edwards, Stefan Sjöberg, Jörgen Carlsson, więcej

Nuclear Medicine and Biology > 2006 > 33 > 6 > 773-783

Auger electron emitters, such as ¹²⁵ I, are getting increasingly wider recognition as alternatives to current anticancer treatments. The effectiveness of Auger electrons is strongly dependent on their proximity to DNA and is therefore considered as harmless outside the nucleus. ¹²⁵ I or ¹²⁷ I was conjugated with Comp1, Comp2 or Comp3 — three derivatives of the chemotherapeutic...

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Evaluation of ((4-Hydroxyphenyl)ethyl)maleimide for Site-Specific Radiobromination of Anti-HER2 Affibody

Eskender Mume, Anna Orlova, Barbro Larsson, Ann-Sofie Nilsson, więcej

Bioconjugate Chemistry > 2005 > 16 > 6 > 1547 - 1555

artykuł

Radiobromination of humanized anti-HER2 monoclonal antibody trastuzumab using N-succinimidyl 5-bromo-3-pyridinecarboxylate, a potential label for immunoPET

Eskender Mume, Anna Orlova, Per-Uno Malmström, Hans Lundqvist, więcej

Nuclear Medicine and Biology > 2005 > 32 > 6 > 613-622

Combining the specificity of radioimmunoscintigraphy and the high sensitivity of PET in an in vivo detection technique could improve the quality of nuclear diagnostics. Positron-emitting nuclide ⁷⁶ Br (T _1/2 =16.2 h) might be a possible candidate for labeling monoclonal antibodies (mAbs) and their fragments, provided that the appropriate labeling chemistry has been established. For...

artykuł

The synthesis of functional derivatives of the [1-CB9H10]− anion by Brellochs reaction

Igor B. Sivaev, Zoya A. Starikova, Pavel V. Petrovskii, Vladimir I. Bregadze, więcej

Journal of Organometallic Chemistry > 2005 > 690 > 11 > 2790-2795

Reactions of decaborane with various aldehydes in alkaline media were studied. The reactions with HCOH and 2-MeOC ₆ H ₄ CHO give the corresponding arachno-carboranes [6-R-arachno-CB ₉ H ₁₃ ] ⁻ (R=H, C ₆ H ₄ -2-OMe), whereas the reactions with C ₆ H ₅ CHO, 4-BrC ₆ H ₄ CHO, 4-MeCONHC ₆ H ₄ CHO, and...

artykuł

Enantioselective synthesis of m-carboranylalanine, a boron-rich analogue of phenylalanine

Charlotta Naeslund, Senait Ghirmai, Stefan Sjöberg

Tetrahedron > 2005 > 61 > 5 > 1181-1186

The enantiomers of the highly lipophilic α-amino acid m-carboranyl-alanine [3-(1,7-dicarba-closo-dodecaborane(12)-1-yl)-2-aminopropanoic acid], a carborane containing analogue of phenylalanine, have been synthesised via hydroxyamination of the N-acyl derivative formed from 3-(m-carboranyl)propionic acid [3-(1,7-dicarba-closo-dodeca-borane(12)-1-yl)-2-propanoic acid] and Oppolzer's camphor sultam....

artykuł

Synthesis and radioiodination of some daunorubicin and doxorubicin derivatives

Senait Ghirmai, Eskender Mume, Vladimir Tolmachev, Stefan Sjöberg

Carbohydrate Research > 2005 > 340 > 1 > 15-24

Daunorubicin and doxorubicin are efficient agents for cancer treatment. Their clinical efficacy is, however, hampered by their indiscriminant toxicity. This problem may be circumvented by encapsulating the drugs in liposomes and selectively targeting the tumor cells using tumor targeting agents. Furthermore, the antitumor effect could be enhanced by attaching the Auger electron emitter, ¹²⁵ ...

artykuł

New B-substituted derivatives of m-carborane, p-carborane, and cobalt bis(1,2-dicarbollide) anion

Irina P. Beletskaya, Vladimir I. Bregadze, Vasily A. Ivushkin, Pavel V. Petrovskii, więcej

Journal of Organometallic Chemistry > 2004 > 689 > 18 > 2920-2929

The Pd-catalyzed cross-coupling reactions of B–I bond in m- and p-carboranes and cobalt bis(1,2-dicarbollide) anion with organomagnesium and organozinc compounds were studied. Carboranyl derivatives of furan, thiophene, indole, pyridine and quinoline were synthesized. 2-Pyridylethynyl and 3-quinolylethynyl derivatives of p-carborane were prepared by Pd-catalyzed cross-coupling reactions using corresponding...

artykuł

Radiobromination of anti-HER2/neu/ErbB-2 monoclonal antibody using the p-isothiocyanatobenzene derivative of the [ ⁷ ⁶ Br]undecahydro-bromo-7,8-dicarba-nido-undecaborate(1-) ion

Karl Johan Winberg, Mikael Persson, Per-Uno Malmström, Stefan Sjöberg, więcej

Nuclear Medicine and Biology > 2004 > 31 > 4 > 425-433

The monoclonal humanized anti-HER2 antibody trastuzumab was radiolabeled with the positron emitter ⁷ ⁶ Br (T ₁ ₂ =16.2 h). Indirect labeling was performed using the p-isothiocyanatobenzene derivative of the [ ⁷ ⁶ Br]undecahydro-bromo-7,8-dicarba-nido-undecaborate(1-) ( ⁷ ⁶ Br-NBI) as a precursor molecule. ⁷ ⁶ Br-NBI was prepared by bromination...

artykuł

Radiobromination of monoclonal antibody using potassium [ ⁷ ⁶ Br] (4 isothiocyanatobenzyl-ammonio)-bromo-decahydro-closo-dodecaborate (Bromo-DABI)

Alexander Bruskin, Igor Sivaev, Mikael Persson, Hans Lundqvist, więcej

Nuclear Medicine and Biology > 2004 > 31 > 2 > 205-211

The use of charged linkers in attaching radiohalogens to tumor-seeking biomolecules may improve intracellular retention of the radioactive label after internalization and degradation of targeting proteins. Derivatives of polyhedral boron clusters, such as closo-dodecaborate (2-) anion, might be possible charged linkers. In this study, a bifunctional derivative of closo-dodecaborate, (4-isothiocyanatobenzyl-ammonio)-undecahydro-closo-dodecaborate...

artykuł

[C ₂ B ₁ ₀ ] [B ₁ ₂ ] double cage boron compounds-a new approach to the synthesis of water-soluble boron-rich compounds for BNCT

Igor B. Sivaev, Stefan Sjöberg, Vladimir I. Bregadze

Journal of Organometallic Chemistry > 2003 > 680 > 1-2 > 106 - 110

A new approach in the synthesis of water-soluble boron-rich compounds was proposed. The closo-dodecaborate cage is used as a hydrophilic substitutent providing for the water-solubility of the molecule whereas the carborane cage can be used for attachment to biomolecules using earlier developed methods. The double-cage molecules [o-, m-, and p-CB ₁ ₀ H ₁ ₀ C(CH ₂ ) ...

artykuł

High yield [ ¹ ² ⁵ I]iodide-labeling of iodinated carboranes by palladium-catalyzed isotopic exchange

Karl Johan Winberg, Gemma Barberà, Ludvig Eriksson, Francesc Teixidor, więcej

Journal of Organometallic Chemistry > 2003 > 680 > 1-2 > 188 - 192

We have recently shown the feasibility of palladium-catalyzed isotopic exchange between [ ¹ ² ⁵ I]iodide and 2-iodo-para-carborane. In this work we have modified the methodology and extended its application to a wider range of iodinated carboranes. Thus, by using Herrmann's catalyst in toluene at 100 ^o C, 2-I-p-, 3-I-o-, 9-I-o-, 9-I-m-carborane, 1-phenyl-3-I-o-carborane and...

artykuł

Chameleonic Capacity of [3,3‘-Co(1,2-C ₂ B ₉ H ₁₁ ) ₂ ] ^- in Coordination. Generation of the Highly Uncommon S(thioether)−Na Bond

Francesc Teixidor, Josefina Pedrajas, Isabel Rojo, Clara Viñas, więcej

Organometallics > 2003 > 22 > 17 > 3414 - 3423

artykuł

Palladium-Catalyzed Heck Reactions of Styrene Derivatives and 2-Iodo- p -carborane

Ludvig Eriksson, Karl Johan Winberg, Rodrigo Tascon Claro, Stefan Sjöberg

The Journal of Organic Chemistry > 2003 > 68 > 9 > 3569 - 3573

artykuł

Ligand Liposomes and Boron Neutron Capture Therapy

Jörgen Carlsson, Erika Bohl Kullberg, Jacek Capala, Stefan Sjöberg, więcej

Journal of Neuro-Oncology > 2003 > 62 > 1 > 47-59

Boron neutron capture therapy (BNCT) has been used both experimentally and clinically for the treatment of gliomas and melanomas, with varying results. However, the therapeutic effects on micro-invasive tumor cells are not clear. The two drugs that have been used clinically, p-boronophenylalanine, (BPA), and the sulfhydryl borane, (BSH), seem to be taken up preferentially in solid tumor areas but...

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