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In this work, we propose a novel genetic pathway discovery and comparison analysis framework integrating newly generated gene expression microarray data and existing biological pathway information. Starting with the significance analysis of microarray (SAM), a list of differentially expressed genes among groups is obtained. This gene list is then imported to the Ingenuity Pathway Analysis (IPA) to...
Whole human genome (Agilent) expression profiling was conducted on disease-unaffected ileal RNA collected from the proximal margin of resected ileum from 47 ileal Crohn's disease (CD), 27 ulcerative colitis (UC) and 25 control patients without inflammatory bowel diseases (IBD). Cluster analysis combined with significance analysis of microarrays (SAM) and principal component analysis (PCA) and was...
To detect the residue of polycyclic aromatic hydrocarbons (PAHs) in the environment quickly by immune method, preparation of high quality antibody against PAHs is the most critical step of the project As the first step toward developing sensitive enzyme linked immunosorbent assays (ELISAs) for selective detection of anthracene in environment, a new hapten was synthesized by the Friedel-Crafts acylation...
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