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Mortality risk‐adjustment comorbidity indices are an efficient means of controlling for the important confounding effect of somatic and psychiatric comorbidities in observational mortality studies. We carried out an external validation study and compared the performance of the Charlson, Elixhauser and Epilepsy‐specific (ES) indices using the National General Practice Study of Epilepsy, a community‐based...
The reported incidence (rate of new cases in a population) of epilepsy is consistently lower in high‐income than in lower‐income economies, whereas opinions vary regarding comparative prevalence rates (proportion of the population with epilepsy). For any condition that does not influence mortality, lifetime prevalence should approximate to the cumulative incidence. We suspected that epilepsy prevalence...
Purpose: Detailed data on the mortality of epilepsy are still lacking from resource‐poor settings. We conducted a long‐term follow‐up survey in a cohort of people with convulsive epilepsy in rural areas of China. In this longitudinal prospective study we investigated the causes of death and premature mortality risk among people with epilepsy.
Methods: We attempted to trace all 2,455 people who had...
Purpose: It is now generally accepted that people with epilepsy are at increased risk of premature death compared with peers in the general population. It has, however, not been clearly established how this risk changes over time, nor whether mortality rates have been changing over time.
Methods: We carried out a systematic review: (1) To determine the pattern of change of mortality risk relative...
Purpose: We attempted to establish whether month and season, or lunar phase, are risk factors for sudden unexpected death in epilepsy (SUDEP), as these have all been suggested as potential risk factors.
Methods: We used the dataset of the National Sentinel Clinical Audit of Epilepsy‐Related Death; all death certificates of people who died in England and Wales between September 1999 and August 2000...
Purpose: To determine whether abnormal cardiac repolarization and other electrocardiography (ECG) predictors for cardiac mortality occur in epilepsy patients and whether they are associated with an increased risk for sudden unexpected death in epilepsy (SUDEP).
Methods: In a matched‐pair case–control study, recordings of adult patients with pharmacoresistant focal epilepsies who died from SUDEP...
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