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A rapid, label-free assay using photonic crystal biosensors for the direct detection of intact viable rotaviruses is demonstrated. This paper describes the design and operation of the biosensor, surface functionalization with anti-rotavirus antibody, characterization of the detection sensitivity, and demonstration of specificity with respect to non-target virus particles. A 30-min assay of a partially...
A photonic crystal biosensor incorporating a nanomolded porous dielectric is fabricated for the first time on a flexible polysulfone substrate. The plastic substrate necessitates several changes to the fabrication procedure, including reduced processing temperatures. The resulting structure shows excellent response uniformity across a large area in the steady state as well as for perturbations of...
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