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We examined possible age- and gender-related changes in binding of the selective antagonist N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1,3-thiazol-2-yl]-4-11C-methoxy-N-methylbenzamide (11C-ITMM) to metabotropic glutamate receptor type 1 in healthy human brains. Dynamic 11C-ITMM positron emission tomography scans (90 min) with serial arterial blood sampling were performed in 15 young and 24 older healthy...
We evaluated in vivo the effect of aging on the sigma 1 receptors in the monkey brain by the quantitative analysis of the binding of [ 11 C]SA4503 to sigma 1 receptors with positron emission tomography. Based on a three-compartment model, the influx rate constant K 1 of [ 11 C]SA4503 from plasma to brain across the blood-brain barrier in all 10 regions...
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