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Background
Coffee intake can decrease the risk for Parkinson's disease (PD). Its beneficial effects are allegedly mediated by caffeine through adenosine A2A receptor (A2AR) antagonist action.
Objective
We aimed to calculate occupancy rates of striatal A2ARs by caffeine after coffee intake in PD.
Methods
Five patients with PD underwent 11C‐preladenant positron emission tomography scanning at baseline...
Background and Purpose
Little evidence exists on the role of type 1 metabotropic glutamate receptor (mGluR1) in the pathophysiology of Alzheimer's disease (AD), although mGluR1 may be involved in the regulation of neuronal excitability and synaptic plasticity. We have recently reported that mGluR1 availability in the early stage of AD is equivalent to that in healthy subjects. This study aimed to...