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Purpose To study new skin penetration/permeation enhancers based on amphiphilic galactose derivatives. Methods Two series of alkyl and alkenyl galactosides were synthesized and evaluated for their enhancing effect on transdermal/topical delivery of theophylline (TH), hydrocortisone (HC) and cidofovir (CDV), reversibility of their effects on transepidermal water loss (TEWL) and skin impedance, interaction...
Purpose Skin permeation/penetration enhancers are substances that enable drug delivery through or into the skin. Methods To search for new enhancers with high but reversible activity and acceptable toxicity, we synthesized a series of d-glucose derivatives, both hydrophilic and amphiphilic. Results Initial evaluation of the ability of these sugar derivatives to increase permeation and penetration...
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