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The optically assisted ultrasonic velocity-change imaging method was applied to obtain the spectroscopic image of nano-particles, which were expected as markers for drug delivery system and photo-thermal therapy, in tissue mimic phantoms. Phantoms including gold nano-rods or semiconductor nano-particles were prepared. The ultrasonic velocity-change images of phantoms were obtained using illumination...
We could obtain ultrasonic velocity change images of Au nano-particles in the two phantoms which ware made of highly optical scattering ager and the chicken breast meet by using the remodeled diagnostic ultrasound equipment. All experimental results suggested that our imaging method could be applied to a practical monitor for the thermal therapy and the drug delivery system (DDS), and could be applied...
Aiming at a realization of effective and less invasive cancer screening tests and therapies using Au nanoparticles which tend to aggregate around cancer parts, the distributional region of Au nanoparticles within a scattering medium of agar was detected by applying an image reconstruction method of the ultrasonic velocity change imaging.
Optical absorption images of the tissue mimic phantom including gold nanoparticles were obtained by detecting the ultrasonic velocity-change caused by light irradiation. A series of experimental results showed the possibility as a nanoparticle distribution monitor for the drug delivery system.
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