Jian Jian Li

article

Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity

Richard C. Miller, Jeffrey S. Murley, Alfred W. Rademaker, Gayle E. Woloschak, more

Free Radical Biology and Medicine > 2016 > 99 > C > 110-119

Exposure of cells to a dose of ionizing radiation as low as 5mGy can induce changes in radiation sensitivity expressed by cells exposed to subsequent higher doses at later times. This is referred to as an adaptive effect. We describe a unique survivin-associated adaptive response in which increased radiation resistance or sensitization of cells can be induced by exposure to 5mGy or to the reactive...

article

Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes

Junjian Wang, Zhijian Duan, Zoann Nugent, June X. Zou, more

Cancer Letters > 2016 > 378 > 2 > 69-79

Metabolic reprogramming such as the aerobic glycolysis or Warburg effect is well recognized as a common feature of tumorigenesis. However, molecular mechanisms underlying metabolic alterations for tumor therapeutic resistance are poorly understood. Through gene expression profiling analysis we found that histone H3K36 methyltransferase NSD2/MMSET/WHSC1 expression was highly elevated in tamoxifen-resistant...

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Efficient virus-induced gene silencing in Cynodon dactylon and Zoysia japonica using rice tungro bacilliform virus vectors

Bing Zhang, Jin-Ang Shi, Jing-Bo Chen, Dan-Dan Li, more

Scientia Horticulturae > 2016 > 207 > C > 97-103

Cynodon dactylon and Zoysia japonica are two important warm-season turfgrass species with multiple utilizations. Genetic transformations of Cynodon dactylon and Zoysia japonica are extremely difficult, which severely restrict the gene functional studies and molecular breeding research of the two grasses. By contrast, virus-induced gene silencing (VIGS) presents an effective and rapid alternative method...

article

All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy

Yunwen Yan, Zhen Li, Xiang Xu, Clark Chen, more

BMC Complementary and Alternative Medicine > 2016 > 16 > 1 > 1-11

Background Radiotherapy is of critical importance in the treatment of breast cancer. However, not all patients derive therapeutic benefit and some breast cancers are resistant to the treatment, and are thus evidenced with prospective distant metastatic spread and local recurrence. In this study, we investigated the potential therapeutic effects of all-trans retinoic acid (ATRA) on radiation-resistant...

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CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair

Lili Qin, Ming Fan, Demet Candas, Guochun Jiang, more

Cell Reports > 2015 > 13 > 10 > 2056-2063

Nuclear DNA repair capacity is a critical determinant of cell fate under genotoxic stress conditions. DNA repair is a well-defined energy-consuming process. However, it is unclear how DNA repair is fueled and whether mitochondrial energy production contributes to nuclear DNA repair. Here, we report a dynamic enhancement of oxygen consumption and mitochondrial ATP generation in irradiated normal cells,...

article

Enhanced anti-colon cancer immune responses with modified eEF2-derived peptides

Weihong Sun, Xiaofang Wei, Airong Niu, Xuezhen Ma, more

Cancer Letters > 2015 > 369 > 1 > 112-123

Eukaryotic elongation factor-2 (eEF2) is overexpressed in many human cancers and is an attractive target for cancer immunotherapy. The eEF2 derived polypeptides have been shown to be able to induce cytotoxic T lymphocytes from healthy donor. Here, we demonstrate the evidence indicating that modification of a segment of peptides from wild type eEF2-derived immunogenic peptides is able to further enhance...

article

CDK1-Mediated Mitochondrial Energy Metabolism Fuels DNA Repair in Irradiated Normal Cells

Lili Qin, Ming Fan, Demet Candas, Gayle Woloschak, more

Free Radical Biology and Medicine > 2015 > 87 > S1 > S151

article

CDK4-mediated MnSOD activation and mitochondrial homeostasis in radioadaptive protection

Cuihong Jin, Lili Qin, Yan Shi, Demet Candas, more

Free Radical Biology and Medicine > 2015 > 81 > C > 77-87

Mammalian cells are able to sense environmental oxidative and genotoxic conditions such as the environmental low-dose ionizing radiation (LDIR) present naturally on the earth’s surface. The stressed cells then can induce a so-called radioadaptive response with an enhanced cellular homeostasis and repair capacity against subsequent similar genotoxic conditions such as a high dose radiation. Manganese...

article

The network of epithelial–mesenchymal transition: potential new targets for tumor resistance

Danupon Nantajit, Dong Lin, Jian Jian Li

Journal of Cancer Research and Clinical Oncology > 2015 > 141 > 10 > 1697-1713

Purpose In multiple cell metazoans, the ability of polarized epithelial cells to convert to motile mesenchymal cells in order to relocate to another location is governed by a unique process termed epithelial–mesenchymal transition (EMT). While being an essential process of cellular plasticity for normal tissue and organ developments, EMT is found to be involved in an array of malignant phenotypes...

article

Enhanced Mitochondrial Bioenergetics in Genotoxic Stress Induced Adaptive Response

Lili Qin, Larry S. Wu, Ming Fan, Jian Jian Li

Free Radical Biology and Medicine > 2014 > 76 > Supplement 1 > S151

article

Breast cancer stem cells: Multiple capacities in tumor metastasis

Shao-Qing Geng, Aris T. Alexandrou, Jian Jian Li

Cancer Letters > 2014 > 349 > 1 > 1-7

Breast cancer is the leading cause of cancer death among women worldwide. Accumulating evidence indicates that the local recurrent and/or distant metastatic tumors, the major causes of lethality in the clinic, are related to the aggressive phenotype of a small fraction of cancer cells loosely termed as cancer stem cells (CSCs), tumor initiating cells (TICs), or cancer metastasis-initiating cells (CMICs)...

article

Cyclin B1/Cdk1 Coordinates Mitochondrial Respiration for Cell-Cycle G2/M Progression

Zhaoqing Wang, Ming Fan, Demet Candas, Tie-Qiao Zhang, more

Developmental Cell > 2014 > 29 > 2 > 217-232

A substantial amount of mitochondrial energy is required for cell-cycle progression. The mechanisms underlying the coordination of the mitochondrial respiration with cell-cycle progression, especially the G2/M transition, remain to be elucidated. Here, we show that a fraction of cyclin B1/Cdk1 proteins localizes to the matrix of mitochondria and phosphorylates a cluster of mitochondrial proteins,...

article

Breast cancer adaptive resistance: HER2 and cancer stem cell repopulation in a heterogeneous tumor society

Nadire Duru, Demet Candas, Guochun Jiang, Jian Jian Li

Journal of Cancer Research and Clinical Oncology > 2014 > 140 > 1 > 1-14

Purpose The lethal effects of cancer are associated with the enhanced tumor aggressiveness in recurrent and metastatic lesions that show resistant phenotype to anti-cancer therapy, a major barrier to improving overall survival of cancer patients. The presence of heterogeneous populations of cancer cells within a specific tumor including the tumor-initiating cells or so-called cancer stem cells (CSCs)...

article

Manganese superoxide dismutase interacts with a large scale of cellular and mitochondrial proteins in low-dose radiation-induced adaptive radioprotection

Angela Eldridge, Ming Fan, Gayle Woloschak, David J. Grdina, more

Free Radical Biology and Medicine > 2012 > 53 > 10 > 1838-1847

The cellular adaptive response to certain low-level genotoxic stresses, including exposure to low-dose ionizing radiation (LDIR), shows promise as a tool to enhance radioprotection in normal cells but not in tumor cells. Manganese superoxide dismutase (MnSOD), a fundamental mitochondrial antioxidant in mammalian cells, plays a key role in the LDIR-induced adaptive response. In this study, we aimed...

article

mTOR Switches Aerobic Glycolysis to Oxidative Phosphrylation in Cellular Bioenergetics Under Radiation

Chung-Ling Lu, Jian Jian Li

Free Radical Biology and Medicine > 2012 > 53 > Supplement 2 > S46

article

Manganese Superoxide Dismutase Interacts with a Large Scale of Cellular and Mitochondrial Proteins in Low Dose Radiation-Induced Adaptive Radioprotection

Angela Eldridge, Ming Fan, Brett Chromy, Jian-Jian Li

Free Radical Biology and Medicine > 2012 > 53 > Supplement 2 > S144

article

Phosphorylation of MnSOD Protein at Serine-106 by Mitochondrial CyclinD1/CDK4 Enhances MnSOD Enzymatic Activity in Radiation-Induced Adaptive Response

Cuihong Jin, Yan Shi, Demet Candas, Ming Fan, more

Free Radical Biology and Medicine > 2012 > 53 > Supplement 2 > S110

article

Potential use of nucleic acid-based agents in the sensitization of nasopharyngeal carcinoma to radiotherapy

Lu Zhang, Lifang Yang, Jian Jian Li, Lunquan Sun

Cancer Letters > 2012 > 323 > 1 > 1-10

Nasopharyngeal carcinoma (NPC) is a highly metastatic cancer. The 2-year survival rate of patients with stage III or IV disease is only about 50%. Due to its high radiosensitivity, radiotherapy is the standard treatment for early-stage of NPC. However, the radioresistance observed in some patients can cause distant metastases and local recurrence after radiotherapy. Special emphasis has been given...

article

NF kappaB and Cdk1 Co-regulated SIRT3 Promotes Tumor Cells Survival by Deacetylation of Mitochondria Proteins Under Stress

Rui Liu, Ming Fan, Chunxu Hai, Jian Jian Li

Free Radical Biology and Medicine > 2011 > 51 > Supplement > S125

article

Coactivation of ATM/ERK/NF-κB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes

Kazi Mokim Ahmed, Danupon Nantajit, Ming Fan, Jeffrey S. Murley, more

Free Radical Biology and Medicine > 2009 > 46 > 11 > 1543-1550

Elucidating the molecular mechanism of the low-dose radiation (LDR)-mediated radioadaptive response is crucial for inventing potential therapeutic approaches to improving normal tissue protection in radiation therapy. ATM, a DNA-damage sensor, is known to activate the stress-sensitive transcription factor NF-κB upon exposure to ionizing radiation. This study provides evidence of the cooperative functions...

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Search results for: Jian Jian Li

Very low doses of ionizing radiation and redox associated modifiers affect survivin-associated changes in radiation sensitivity

Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes

Efficient virus-induced gene silencing in Cynodon dactylon and Zoysia japonica using rice tungro bacilliform virus vectors

All-trans retinoic acids induce differentiation and sensitize a radioresistant breast cancer cells to chemotherapy

CDK1 Enhances Mitochondrial Bioenergetics for Radiation-Induced DNA Repair

Enhanced anti-colon cancer immune responses with modified eEF2-derived peptides

CDK1-Mediated Mitochondrial Energy Metabolism Fuels DNA Repair in Irradiated Normal Cells

CDK4-mediated MnSOD activation and mitochondrial homeostasis in radioadaptive protection

The network of epithelial–mesenchymal transition: potential new targets for tumor resistance

Enhanced Mitochondrial Bioenergetics in Genotoxic Stress Induced Adaptive Response

Breast cancer stem cells: Multiple capacities in tumor metastasis

Cyclin B1/Cdk1 Coordinates Mitochondrial Respiration for Cell-Cycle G2/M Progression

Breast cancer adaptive resistance: HER2 and cancer stem cell repopulation in a heterogeneous tumor society

Manganese superoxide dismutase interacts with a large scale of cellular and mitochondrial proteins in low-dose radiation-induced adaptive radioprotection

mTOR Switches Aerobic Glycolysis to Oxidative Phosphrylation in Cellular Bioenergetics Under Radiation

Manganese Superoxide Dismutase Interacts with a Large Scale of Cellular and Mitochondrial Proteins in Low Dose Radiation-Induced Adaptive Radioprotection

Phosphorylation of MnSOD Protein at Serine-106 by Mitochondrial CyclinD1/CDK4 Enhances MnSOD Enzymatic Activity in Radiation-Induced Adaptive Response

Potential use of nucleic acid-based agents in the sensitization of nasopharyngeal carcinoma to radiotherapy

NF kappaB and Cdk1 Co-regulated SIRT3 Promotes Tumor Cells Survival by Deacetylation of Mitochondria Proteins Under Stress

Coactivation of ATM/ERK/NF-κB in the low-dose radiation-induced radioadaptive response in human skin keratinocytes

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