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A recent study showed that SKF92374, a structural analog of the histamine H 2 receptor antagonist cimetidine, induces antinociception after intraventricular (i.v.t.) administration in the rat. SKF92374 lacked significant activity on H 1 or H 2 receptors, but had weak activity on H 3 receptors. To test the hypothesis that SKF92374-induced antinociception is mediated...
The effects of the brain-penetrating H 2 antagonist zolantidine (ZOL, 3 mg/kg, s.c.) were studied on morphine (MOR, 4 mg/kg, s.c.) antinociception (tail flick test) in the presence and absence of previous restraint stress. Animals were handled for 3 days (to reduce handling stress), restrained for 1 hr or handled on day 4, and tested 24 hrs later. As found previously, restraint enhanced the...
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