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Small-molecule library screening to find compounds that inhibit TNFα-induced, but not interleukin 1β (IL-1β)-induced, intercellular adhesion molecule 1 (ICAM-1) expression in lung epithelial cells identified a class of triazoloquinoxalines. These compounds not only inhibited the TNFα-induced nuclear factor κB (NFκB) survival pathway but also blocked death-pathway activation. Such dual activity makes...
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