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Dipeptidyl peptidase-IV (DPP-IV), an enzyme that degrades incretins–hormones that promote insulin secretion–is a therapeutic target for type 2 diabetes, with a number of its inhibitors having been launched as therapies for diabetes. Since adverse effects of these inhibitors have recently been reported, the development of novel DPP-IV inhibitors with higher efficacy and safety is required. We, therefore,...
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